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Drug-Drug Interaction Study With PF-05089771

Pfizer logo

Pfizer

Status and phase

Completed
Phase 1

Conditions

Healthy

Treatments

Drug: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771

Study type

Interventional

Funder types

Industry

Identifiers

NCT01934569
B3291023

Details and patient eligibility

About

This study will test the potential for PF-05089771 to interact with a cocktail of drugs

Enrollment

17 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy male and/or female subjects between the ages of 18 and 55 years;
  • Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs);

Exclusion criteria

  • Any condition possibly affecting drug absorption
  • History of regular alcohol consumption
  • Screening supine blood pressure >140 mm Hg (systolic) or >90 mm Hg (diastolic),
  • Consumption of coffee, cola or other caffeine containing drinks

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

17 participants in 1 patient group

Active tratment
Experimental group
Description:
Pravastatin, midazolam, losartan, omeprazole, caffeine single dose alone or in combination with PF-05089771
Treatment:
Drug: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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