Drug-Drug Interaction Study With PF-05089771

Pfizer

Status and phase: Completed; Phase 1

Conditions: Healthy

Treatments: Drug: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771

Study type: Interventional

Funder types: Industry

Identifiers

NCT01934569

B3291023

Details and patient eligibility

About

This study will test the potential for PF-05089771 to interact with a cocktail of drugs

Enrollment: 17 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male and/or female subjects between the ages of 18 and 55 years;
• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs);

Exclusion criteria

• Any condition possibly affecting drug absorption
• History of regular alcohol consumption
• Screening supine blood pressure >140 mm Hg (systolic) or >90 mm Hg (diastolic),
• Consumption of coffee, cola or other caffeine containing drinks

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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17 participants in 1 patient group

Active tratment

Experimental group

Description:

Pravastatin, midazolam, losartan, omeprazole, caffeine single dose alone or in combination with PF-05089771

Treatment:

Drug: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771