Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs)

Chulalongkorn University

Status: Unknown

Conditions: Drug Reaction

Treatments: Other: patch test

Study type: Interventional

Funder types: Other

Identifiers

NCT03176342

204/59

Details and patient eligibility

About

The study is about drug patch tests in patients who have history of severe cutaneous drug reaction including Steven Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), Drug-induced eosinophilia and systemic symptoms (DRESS), AGEP (Acute generalized exanthematous pustulosis) and generalized bullous fixed drug eruptions. This study also investigate in Enzyme-linked immunosorbent spot assay (ELIspot) and lymphocyte transformation test. We also trying to prove the correlation among result of drug patch tests, ELIspot and LTT.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with history of Steven Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug-induced eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), generalized bullous fixed drug eruption in the past 24 months.
• Age more than 18 years old

Exclusion criteria

• Receiving immunosuppressive drugs or more than 10 mg/day of prednisolone within 1 month.
• Pregnancy and lactation

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

patch test arm

Experimental group

Description:

Patch test by selected allergens and drawing blood for ELIspot and LTT

Treatment:

Other: patch test