Dry Eye Evaluation System Based on Bioinformatics

Huaxia Eye Hospital Group

Status

Unknown

Conditions

Dry Eye

Study type

Observational

Funder types

Other

Identifiers

NCT04109170

FSHX2019-01

Details and patient eligibility

About

Dry eye is a common ocular surface disease of multifactorial etiology characterized by elevated tear osmolality and inflammation leading to a disrupted ocular surface. The latter is a risk factor for ocular surface infection, yet overt infection is not commonly seen clinically in the typical dry eye patient. This suggests that important innate mechanisms operate to protect the dry eye from invading pathogens. Understand the pathogenesis of dry eye will be the measure to prevention and treatment of dry eye.

In this essay, the investigators use the data of experiment in the patients with dry eye and normal, acquire their tear production, tear film stability, and surface damage. The investigators use weka to calculate the prediction accuracy of the 6 algorithm and select the best one, optimize the parameters to get the final prediction accuracy.

Enrollment

500 estimated patients

Sex

All

Ages

10 to 90 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Clinical diagnosis of Dye Eye

Exclusion criteria

systemic disease (such as diabetes, glaucoma, or systemic collagen vascular disease), ocular disease, a history of tear supplement usage or contact lens wear during the past year,and pregnancy