dTDI During a SBT to Predict Extubation Failure in Preterm Infants

Wang Jianhui

Status

Enrolling

Conditions

Premature

Treatments

Device: diaphragmatic tissue Doppler imaging，dTDI

Study type

Observational

Funder types

Other

Identifiers

NCT05865977

20230223

Details and patient eligibility

About

Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure. the aim of present investigation is to evaluate diaphragmatic excursion velocity during in patients undergoing spontaneous breathing trial through tissue Doppler analysis in both inspiration and expiration.

Enrollment

100 estimated patients

Sex

All

Ages

2 days to 6 months old

Volunteers

No Healthy Volunteers

Inclusion criteria

premature infants with gestational age <32 weeks and supported by invasive mechanical ventilation ≥48 hours
All the indications for extubation are met：cough or vomiting due to spontaneous breathing and sputum aspiration; ventilator parameters in recent 24 hours: MAP < 8cmH2O, RR < 30 times/min, FiO2 < 30%; Arterial blood gas: pH > 7.25, (PaCO2< 60mmHg, BE < 8mmol/L, oxygen saturation > 90%
a successful SBT
parents or legal guardians sign informed consent to attend this study

Exclusion criteria

accidental extubation
chest CT or bronchoscopy during hospitalization indicated congenital airway dysplasia
complex congenital heart disease
congenital metabolic diseases, neuromuscular diseases
severe brain injury
surgical mechanical ventilation
give up before extubation;
pneumothorax or pleural effusion
no consent is signed