Dual Antiplatelet Therapy (DAPT) in Patients With Baseline Thrombocytopenia

M

Methodist Health System

Status

Enrolling

Conditions

Baseline Thrombocytopenia

Study type

Observational

Funder types

Other

Identifiers

NCT06223607
036.PHA.2022.D

Details and patient eligibility

About

The use of clopidogrel as part of DAPT will be associated with lower bleeding rates compared to ticagrelor in patients with chronic thrombocytopenia requiring Percutaneous intervention (PCI )with Drug Eluting Stent (DES) or Bare Metal Stint(BMS).

Full description

Patients with thrombocytopenia are at an increased risk of both bleeding and ischemic events following PCI; however, there is a paucity of data on how to optimally manage these risks. Data indicates that ticagrelor is associated with reduced ischemic outcomes with an accompanying increased risk of bleed in the broader population. This study will assess P2Y12 agent selection in patients with chronic thrombocytopenia to determine if one better balances risks of ischemic and bleeding events following coronary intervention

Enrollment

300 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ≥ 18 years
  • PCI with either DES or BMS during study time period (April 1, 2018 through July 1 2021)
  • Thrombocytopenia defined as platelet count <100 x103 /µL on at least one occasion prior to PCI
  • At least one dose of DAPT post-PCI with aspirin and either clopidogrel or ticagrelor

Exclusion criteria

  • Death within 48 hours post-PCI
  • DAPT prior to cardiac catheterization

Trial contacts and locations

1

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Central trial contact

Bethany Brauer; Colette Ngo Ndjom

Data sourced from clinicaltrials.gov

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