Dual Channel Rehabilitation Technology Promotes Rapid Recovery of Upper Limbs After Stroke

Fu Xing Hospital, Capital Medical University

Status: Enrolling

Conditions: Stroke; Upper Extremity Dysfunction; Transcranial Direct Current Stimulation; Image, Body

Treatments: Behavioral: Transcranial Direct Current Stimulation and motor imagery therapy; Behavioral: Transcranial Direct Current Stimulation therapy; Behavioral: Motor imagery therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT04944680

2021FXHEC-KSKY002

Details and patient eligibility

About

The injury and remodeling mechanism about upper extremity motor network after stroke is not clear. There are few studies on the motor network covering cortex, white matter and blood perfusion at the time. Some studies have shown that metal imagery activates the cortex through active mental simulation. Our previous study has shown that passive application of transcranial direct current stimulation causes subthreshold polarization and promotes the effective integration of residual brain high-level network. This study proposes a hypothesis: transcranial Direct Current Stimulation + Motor Imagery combines active and passive neuromodulation techniques to produce dual channel effect, which can synergistically excite motor cortex, remodel the motor network and optimize cerebral perfusion. The research contents include clarify the effect of transcranial Direct Current Stimulation + Motor Imagery neuromodulation therapy through comprehensive randomized controlled trial study; present the process of brain injury and secondary neural plasticity through the motor network construction, functional connectivity strength and cerebral perfusion with Blood Oxygen Level Dependent, Diffusion Tensor Imaging and Arterial Spin Labeling multimodal magnetic resonance technology; calculate the correlation between motor score and brain functional network, extract the key nodes that can promote the motor network remodeling. The research results are expected to provide preliminary theoretical foundations for further research on the injury and remodeling mechanism about upper extremity motor network after stroke.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• First stroke with upper limb motor dysfunction
• No rapid natural recovery in the last week
• Greater than 1 month since stroke onset
• Pass the motor imagery test

Exclusion criteria

• Severe cognitive disorder
• Severe spasm or joint contracture
• Mental implants in vivo
• Do not sign the informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 4 patient groups

Control group

No Intervention group

Description:

Stroke patients accept the traditional rehabilitation alone.

Transcranial Direct Current Stimulation group

Active Comparator group

Description:

Stroke patients accept the Transcranial Direct Current Stimulation alone.

Treatment:

Behavioral: Transcranial Direct Current Stimulation therapy

Motor imagery group

Active Comparator group

Description:

Stroke patients do the motor imagery alone.

Treatment:

Behavioral: Motor imagery therapy

Transcranial Direct Current Stimulation and motor imagery group

Experimental group

Description:

Stroke patients accept the Transcranial Direct Current Stimulation and do the motor imagery at the same time.

Treatment:

Behavioral: Transcranial Direct Current Stimulation and motor imagery therapy