Dual Channel Rehabilitation Technology Promotes Rapid Recovery of Upper Limbs After Stroke

F

Fu Xing Hospital, Capital Medical University

Status

Enrolling

Conditions

Stroke
Upper Extremity Dysfunction
Transcranial Direct Current Stimulation
Image, Body

Treatments

Behavioral: Transcranial Direct Current Stimulation and motor imagery therapy
Behavioral: Transcranial Direct Current Stimulation therapy
Behavioral: Motor imagery therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT04944680
2021FXHEC-KSKY002

Details and patient eligibility

About

The injury and remodeling mechanism about upper extremity motor network after stroke is not clear. There are few studies on the motor network covering cortex, white matter and blood perfusion at the time. Some studies have shown that metal imagery activates the cortex through active mental simulation. Our previous study has shown that passive application of transcranial direct current stimulation causes subthreshold polarization and promotes the effective integration of residual brain high-level network. This study proposes a hypothesis: transcranial Direct Current Stimulation + Motor Imagery combines active and passive neuromodulation techniques to produce dual channel effect, which can synergistically excite motor cortex, remodel the motor network and optimize cerebral perfusion. The research contents include clarify the effect of transcranial Direct Current Stimulation + Motor Imagery neuromodulation therapy through comprehensive randomized controlled trial study; present the process of brain injury and secondary neural plasticity through the motor network construction, functional connectivity strength and cerebral perfusion with Blood Oxygen Level Dependent, Diffusion Tensor Imaging and Arterial Spin Labeling multimodal magnetic resonance technology; calculate the correlation between motor score and brain functional network, extract the key nodes that can promote the motor network remodeling. The research results are expected to provide preliminary theoretical foundations for further research on the injury and remodeling mechanism about upper extremity motor network after stroke.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • First stroke with upper limb motor dysfunction
  • No rapid natural recovery in the last week
  • Greater than 1 month since stroke onset
  • Pass the motor imagery test

Exclusion criteria

  • Severe cognitive disorder
  • Severe spasm or joint contracture
  • Mental implants in vivo
  • Do not sign the informed consent

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

80 participants in 4 patient groups

Control group
No Intervention group
Description:
Stroke patients accept the traditional rehabilitation alone.
Transcranial Direct Current Stimulation group
Active Comparator group
Description:
Stroke patients accept the Transcranial Direct Current Stimulation alone.
Treatment:
Behavioral: Transcranial Direct Current Stimulation therapy
Motor imagery group
Active Comparator group
Description:
Stroke patients do the motor imagery alone.
Treatment:
Behavioral: Motor imagery therapy
Transcranial Direct Current Stimulation and motor imagery group
Experimental group
Description:
Stroke patients accept the Transcranial Direct Current Stimulation and do the motor imagery at the same time.
Treatment:
Behavioral: Transcranial Direct Current Stimulation and motor imagery therapy

Trial contacts and locations

1

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Central trial contact

Ran Li, Doctor; Yong Wang, Doctor

Data sourced from clinicaltrials.gov

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