Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy

The Washington University

Status: Terminated

Conditions: Lung Cancer; Head and Neck Cancer; Brain Cancer

Treatments: Device: Siemens Somatom Definition Edge; Device: Philips Brilliance Big Bore CT/simulator

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03403361

201711149

1R01CA212638 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The aim of this protocol is to refine the accuracy of proton beam therapy (PT) by the use of dual energy computed tomography (DECT), in conjunction with novel iterative image reconstruction algorithms, to more precisely determine the tissue properties through which the proton beam path travels.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Eligibility Criteria:

Inclusion Criteria:

• Diagnosis of histologically proven primary or metastatic cancer requiring thoracic radiation therapy OR radiation therapy to the head and neck or brain
• At least 18 years of age.
• Planning to undergo proton or photon beam radiation therapy as part of the clinical management of the diagnosed cancer.
• Able to understand and willing to sign an IRB-approved written informed consent document.

Exclusion Criteria:

• Implanted metallic objects in the region to be scanned excepting dental prostheses
• IV or oral contrast medium within 24 hours prior to DECT image acqusition
• Pregnant.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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36 participants in 1 patient group

Dual-Energy CT scan

Experimental group

Description:

Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.

Treatment:

Device: Siemens Somatom Definition Edge

Device: Philips Brilliance Big Bore CT/simulator