Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions

University Health Network, Toronto

Status: Enrolling

Conditions: Brain Metastases; Brain Tumor

Treatments: Diagnostic Test: Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT05358340

20-6282

Details and patient eligibility

About

The objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (SAGE) sequence in dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with a brain metastasis or primary brain tumour and who will undergo MRI with contrast.

Exclusion criteria

• Subject or subject's legally authorized representative is unable or unwilling to consent to the study.
• Subject with documented contrast medium injection contraindication due to severe kidney disease or allergy.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Diagnostic (DSC MRI)

Experimental group

Treatment:

Diagnostic Test: Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI)