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Dual Site-dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Stroke Patients

Samsung Medical Center logo

Samsung Medical Center

Status

Completed

Conditions

Cognitive Impairment
Stroke
Aphasia

Treatments

Device: IFG stimulation
Device: DLPFC stimulation
Behavioral: aphasia therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT03486782
2017-08-124-B

Details and patient eligibility

About

The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional inferior frontal cortex, ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex. 2) Single stimulation 1: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional inferior frontal cortex; 3) Single stimulation 2: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional supraorbital area.

Enrollment

30 patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • left hemisphere involved stroke patients
  • patients diagnoses as post stroke aphasia

Exclusion criteria

  • history of psychiatric disease
  • patients with metal implants
  • history of epilepsy
  • pregnancy
  • skin defect at the site of electrode attachment

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

30 participants in 3 patient groups

Dual stimulation
Active Comparator group
Description:
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex and cathodal stimulation of contralesional supraorbital area
Treatment:
Device: IFG stimulation
Device: DLPFC stimulation
Behavioral: aphasia therapy
Single stimulation 1
Active Comparator group
Description:
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional inferior frontal cortex
Treatment:
Device: IFG stimulation
Behavioral: aphasia therapy
Single stimulation 2
Active Comparator group
Description:
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area
Treatment:
Device: IFG stimulation
Behavioral: aphasia therapy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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