Dual Site-dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Stroke Patients

Samsung Medical Center

Status: Completed

Conditions: Cognitive Impairment; Stroke; Aphasia

Treatments: Device: IFG stimulation; Device: DLPFC stimulation; Behavioral: aphasia therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03486782

2017-08-124-B

Details and patient eligibility

About

The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional inferior frontal cortex, ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex. 2) Single stimulation 1: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional inferior frontal cortex; 3) Single stimulation 2: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional supraorbital area.

Enrollment: 30 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• left hemisphere involved stroke patients
• patients diagnoses as post stroke aphasia

Exclusion criteria

• history of psychiatric disease
• patients with metal implants
• history of epilepsy
• pregnancy
• skin defect at the site of electrode attachment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 3 patient groups

Dual stimulation

Active Comparator group

Description:

i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex and cathodal stimulation of contralesional supraorbital area

Treatment:

Device: IFG stimulation

Device: DLPFC stimulation

Behavioral: aphasia therapy

Single stimulation 1

Active Comparator group

Description:

i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional inferior frontal cortex

Treatment:

Device: IFG stimulation

Behavioral: aphasia therapy

Single stimulation 2

Active Comparator group

Description:

i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area

Treatment:

Device: IFG stimulation

Behavioral: aphasia therapy