Dual Site-dual Channel Non-invasive Brain Stimulation for Motor Function in Stroke Patients

Samsung Medical Center

Status: Completed

Conditions: Stroke

Treatments: Behavioral: hand motor task; Device: M1 stimulation; Device: aIPS stimulation; Device: PMC stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03486769

2017-08-124-A

Details and patient eligibility

About

The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through three conditions of transcranial direct current stimulation with for 30 minutes. Three conditions are 1) Dual stimulation 1: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. 2) Dual stimulation 2: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. 3) Single stimulation: anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex.

Enrollment: 30 patients

Sex: All

Ages: 19 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• unilateral hemiplegic stroke patient
• Fugl Meyer Assessment score between 9 to 84

Exclusion criteria

• difficult to understand experimental tasks because of extremely severe cognitive impairment
• history of psychiatric disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 3 patient groups

Dual Stimulation 1

Experimental group

Description:

i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area.

Treatment:

Device: PMC stimulation

Device: M1 stimulation

Behavioral: hand motor task

Dual Stimulation 2

Experimental group

Description:

i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area.

Treatment:

Device: aIPS stimulation

Device: M1 stimulation

Behavioral: hand motor task

Single stimulation

Experimental group

Description:

anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex

Treatment:

Device: M1 stimulation

Behavioral: hand motor task