Dual Trigger Versus Booster Dose of HCG

Cairo University (CU)

Status: Completed

Conditions: Infertility

Treatments: Drug: Human Chorionic Gonadotropin; Procedure: IVF/ICSI

Study type: Interventional

Funder types: Other

Identifiers

NCT02397642

12015

Details and patient eligibility

About

To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared dual trigger with GnRH agonist plus 1000 IU of HCG or triggering with GnRH and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.

Enrollment: 200 patients

Sex: Female

Ages: 20 to 37 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• High responder females undergoing antagonist protocol IVF/ICSI cycle
• More than 14 MII oocytes
• Estradiol more than 3500 pg/ml on day of trigger

Exclusion criteria

• Any other protocol
• Normal or poor responders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Dual trigger

Active Comparator group

Description:

GnRH agonist plus 1000 IU of HCG to trigger final maturation

Treatment:

Procedure: IVF/ICSI

Drug: Human Chorionic Gonadotropin

Booster HCG dose

Active Comparator group

Description:

GnRH agonist only to trigger final maturation followed by a booster dose of 1500 IU of HCG on the day of ovum pickup

Treatment:

Procedure: IVF/ICSI

Drug: Human Chorionic Gonadotropin