Duffy-null Associated Neutrphil Count (DANC) Pediatric Patients (DANCChildren)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Neutropenia Autoimmune

Treatments: Other: Data collection and analysis

Study type: Observational

Funder types: Other

Identifiers

NCT06547931

0017727

Details and patient eligibility

About

There are currently no clinical and laboratory data that well characterize this neutropenia associated with the Duffy-null phenotype, particularly for pediatric subjects. In particular there are no data on the frequency of immune neutropenia in DANC neutropenic pediatric subjects.

The goal of this study is to :

• define the frequency of immune neutropenia within the cohort of DANC subjects under study
• evaluate the frequency of different degrees of neutropenia (mild-moderate-severe);
• evaluate the possible association between different degrees of neutropenia and the presence of infections.

Enrollment: 150 estimated patients

Sex: All

Ages: Under 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• presence of Duffy-null phenotype

Exclusion criteria

• absence of Duffy-null phenotype

Trial design

150 participants in 1 patient group

Duffy null neutropenic subjects

Description:

Pediatric patients sent to our laboratory for anti-neutrophil antibodies evaluation in the suspicion of immune neutropenia

Treatment:

Other: Data collection and analysis