Duloxetine Compared to Escitalopram and Placebo in the Treatment of Patients With Depression

Lilly

Status and phase: Completed; Phase 3

Conditions: Depression

Treatments: Drug: duloxetine; Drug: placebo; Drug: escitalopram

Study type: Interventional

Funder types: Industry

Identifiers

NCT00073411

7978

F1J-US-HMCR

Details and patient eligibility

About

The purposes of this study are to determine:

• The safety of duloxetine and any side effects that might be associated with it.
• How duloxetine compares to escitalopram and placebo (an inactive ingredient)

Full description

duloxetine 60mg - 120mg, escitalopram 10mg - 20mg, and placebo, 8-month,

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Must be at least 18 of age
• Must meet the criteria for major depressive disorder
• You must be able to visit the doctor's office about once a week for 2 to 3 months. After that, you will need to visit the doctor's office once a month for about 6 months
• You must be able to take the study drug as prescribed (6 capsules per day taken once-daily)

Exclusion criteria

• You are a woman and are pregnant or breastfeeding.
• You have a current or previous major psychiatric disorder other than depression, such as bipolar disorder, schizophrenia, or other psychotic disorder.
• You have a history of alcohol or drug dependence within the past 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind