Duloxetine for Postoperative Pain of Laparoscopic Cholecystectomy

Mansoura University

Status and phase: Completed; Phase 2

Conditions: Pain, Postoperative

Treatments: Drug: Duloxetine; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05115123

23-2021

Details and patient eligibility

About

Recent studies on the impact of perioperative duloxetine for treatment of acute postoperative pain have yielded positive outcomes with respect to reduction opioid consumption. The aim of the present study is to investigate the role of perioperative duloxetine on the management of postoperative pain in patients undergoing LC.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Patients who are scheduled to undergo elective LC

Exclusion criteria

1- Patients with acute pancreatitis 2. Patients undergoing chronic pain treatment 3. Patients who received analgesics or sedatives 24 h before scheduled surgery 3. Patients had alcohol or drug addiction 4. Severe hepatic and renal dysfunction 5. Previous allergic response to duloxetine 6. Pregnancy and lactation 7. Patients with communication problems, cognitive dysfunction, or psychological disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

Intervention

Active Comparator group

Description:

patients scheduled for elective LC will receive 60 mg duloxetine before surgery

Treatment:

Drug: Duloxetine

Control

Placebo Comparator group

Description:

patients scheduled for elective LC will receive placebo before surgery

Treatment:

Drug: Placebo