Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine

Assiut University

Status: Completed

Conditions: Acute Pain

Treatments: Drug: Duloxetine 60mg; Drug: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03560427

SECI-IRB-IORG0006563-534

Details and patient eligibility

About

Duloxetine is a serotonin-norepinephrine reuptake inhibitor primarily used for treatment of major depression and anxiety. Duloxetine also has been used in the treatment of chronic pain conditions, such as osteoarthritis and musculoskeletal pain. There are few studies examining its effect for acute pain. The objective of this study is to evaluate the analgesic effect of duloxetine combined with intrathecal morphine for patients subjected to major abdominal cancer surgery

Enrollment: 60 patients

Sex: All

Ages: 16 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients, subjected to major abdominal cancer surgery

Exclusion criteria

• patients on chronic opioid therapy
• patients allergic to study drugs (duloxetine+morphine)
• patients have uncontrolled hypertension and or ischemic heart disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

duloxetine+morphine

Experimental group

Treatment:

Drug: Duloxetine 60mg

placebo+morphine

Placebo Comparator group

Treatment:

Drug: placebo