Duodenal Jejunal Bypass for Type 2 Diabetes (DJBD)

Ferzli, George S., M.D. F.A.C.S.

Status and phase: Unknown; Phase 1

Conditions: Diabetes Mellitus

Treatments: Procedure: duodenal jejunal bypass

Study type: Interventional

Identifiers

NCT00487526

AS07006

Details and patient eligibility

About

Study the effect of Duodenal jejunal bypass on human adults with type 2 diabetes.

Full description

Adults non obese ( BMI less than 34 ) will undergo duodenal jejunal bypass. The Outcome measures: Blood Sugar, Insulin,HbA1c, CCK,Gastrin, GIP1and 2, Ghrelin, Cholesterol, Triglycerides,FFA, C-Peptide.

Enrollment: 50 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults age 20-65
• Clinical diagnosis of type 2 diabetes
• Non obese with BMI less than 34.
• Oral agents or insulin to control T2DM.
• Inadequate control of diabetes as defined as HbA1c>/7.5
• Understanding of the mechanisms of action of the treatment

Exclusion criteria

• Children with type 1 diabetes
• Obese with BMI over 34
• Coagulopathy
• Liver cirrhosis
• Unable to comply with study requirements, follow-up or give valid consent
• Currently pregnant
• Previous upper abdominal surgery
• Inabilty to tolerate general anesthesia

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)