Duration of Analgesic Effect for Ultrasound Guided Supraclavicular Blocks With the Addition of Buprenorphine to Local Anesthetic Solution

University of Wisconsin (UW)

Status: Terminated

Conditions: Supraclavicular Block; Regional Block for Pain Control; Block Additive; Ultrasound Guided Block

Treatments: Drug: Buprenorphine

Study type: Interventional

Funder types: Other

Identifiers

NCT01583179

A530900 (Other Identifier)

SMPH/ANESTHESIO (Other Identifier)

2011-0781

Details and patient eligibility

About

The patients included will be those who have already agreed to have a brachial plexus nerve block for surgery. A flip of the coin will decide who gets and additive called buprenorphine in their block or not. They will both contain the same amount and type of numbing medicine. The goal will be to see if the additive extends the life of the pain control portion of the ultrasound guided supraclavicular nerve block.

Enrollment: 26 patients

Sex: All

Ages: 18 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. American Society of Anesthesiologists (ASA) physical status 1-3
2. Age 18-79, inclusive
3. BMI <36 kg/m^2
4. Patient consenting to single injection brachial plexus nerve block as primary anesthetic for a procedure

Exclusion criteria

1. Patients with coagulation disorders
2. Clinically significant pulmonary disease
3. Clinically significant cardiac disease
4. Neurologic deficit in surgical extremity
5. Allergy to bupivacaine or buprenorphine
6. Intolerance of narcotics
7. Local infection over intended area of needle insertion
8. Hepatic failure or renal failure
9. Significant psychiatric disease, including drug abuse
10. Seizure disorder
11. Possible pregnancy or lactation by patient report
12. Use of narcotic medication greater than 2 times a week for greater than 1 week.
13. Patients for whom the surgeon requests a shorter-acting block

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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26 participants in 2 patient groups

Control group

No Intervention group

Description:

will get only local anesthetic and epinephrine in block. no additive in block

buprenorphine

Experimental group

Description:

will receive local anesthetic, epinephrine and the additive buprenorphine to nerve block

Treatment:

Drug: Buprenorphine