Duration of Antibiotic Treatment of Erythema Migrans

University Medical Centre Ljubljana

Status: Completed

Conditions: Erythema Chronicum Migrans

Treatments: Drug: placebo; Drug: doxycycline

Study type: Interventional

Funder types: Other

Identifiers

NCT00910715

EM-0509

Details and patient eligibility

About

The purpose of this study is to compare the efficacy of 15-day versus 10-day doxycycline treatment in patients with erythema migrans.

Enrollment: 306 patients

Sex: All

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• solitary erythema migrans in patients > 15 years

Exclusion criteria

• a history of Lyme borreliosis in the past
• pregnancy or lactation
• immunocompromised status
• serious adverse event to doxycycline
• taking antibiotic with antiborrelial activity within 10 days
• multiple erythema migrans or extracutaneous manifestations of Lyme borreliosis

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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306 participants in 3 patient groups, including a placebo group

EM-10 days doxycycline

Active Comparator group

Treatment:

Drug: doxycycline

Drug: doxycycline

EM-doxycycline 15 days

Active Comparator group

Treatment:

Drug: doxycycline

Drug: doxycycline

controls

Placebo Comparator group

Treatment:

Drug: placebo