Duration of Blockade of Peripheral Nerves With Bupivacaine Depending of the Adjuvants (DBBA)

Lviv National Medical University (LNMU)

Status: Completed

Conditions: Fracture of the Lower Limb (Except Hip), Initial Encounter; Postoperative Pain; Local Anesthetic Systemic Toxicity; Peripheral Neuropathy; Intraoperative Hypertension; Intraoperative Hypotension; Anesthesia, Local; Pain Syndrome; Fractures of the Upper Limb; Anesthesia

Treatments: Drug: Bupivacaine, dexamethasone, epinephrine

Study type: Observational

Funder types: Other

Identifiers

NCT04498923

LNMY-FPGE- ANESTHESIOLOGY-DBBA

Details and patient eligibility

About

The main aim of the investigator's study is to propose combination of local anesthetics and adjuvants that provides both adequate anesthesia during surgery and prolonged post-operative analgesia.

Full description

Peripheral nerve plexuses blocks are performing as a component of analgesia in patients undergoing orthopedic surgery on the upper or lower extremities. Patients are divided into two groups depending on the adjuvant to the local anesthetic: 1st group - patients whose blockade is performed with a solution of bupivacaine 0.375% together with dexamethasone 0.02%; Group 2 - patients whose blockade is performed with a solution of bupivacaine 0.375% together with dexamethasone 0.02% and epinephrine 0.00018%. The duration of the blockade is estimated by puncturing the skin with a needle. The intensity of pain is assessed at 6, 12, 24 and 36 hours after blockade using Visual analog scale (VAS). The amount of narcotic anesthetic used in the postoperative period is also recorded. In addition, patients underwent electromyography of the innervation area of the blocked nerve before the surgery and 24 and 36 hours after surgery.

Enrollment: 68 patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients undergoing upper or lower extremity orthopedic surgery

Exclusion criteria

• diabetes mellitus;
• diseases of the peripheral nerv system

Trial design

68 participants in 2 patient groups

Bupivacaine with dexamethasone

Description:

Ultrasound guided peripheral nerve block for upper or lower extremity was performed before orthopedic surgery using neurostimulator. Twenty milliliters solution of bupivacaine 0,375% with dexamethasone was injected for one plexus or peripheral nerve.

Treatment:

Drug: Bupivacaine, dexamethasone, epinephrine

Bupivacaine with dexamethasone and epinephrine

Description:

Ultrasound guided peripheral nerve block for upper or lower extremity was performed before orthopedic surgery using neurostimulator. Twenty milliliters solution of bupivacaine 0,375% with dexamethasone 0,02% and epinephrine 0,00018% was injected for one plexus or peripheral nerve.

Treatment:

Drug: Bupivacaine, dexamethasone, epinephrine