Duration of Dual Antiretroviral Therapy in Virologically Suppressed People Living With HIV and Factors Associated With Switching to Tritherapy : a Real-life Cohort (TOBIT)

Tourcoing Hospital

Status: Completed

Conditions: HIV Infections

Treatments: Other: dual therapy

Study type: Observational

Funder types: Other

Identifiers

NCT06107140

CHT/URC/2023/13

Details and patient eligibility

About

HIV infection requires lifelong continuous antiretroviral (ARV) treatment. The efficacy of current ARV treatments makes it possible to propose strategies for reducing the cumulative exposure to ARVs, side effects and costs. And so improve the quality of life of people living with HIV (PLHIV). However, in the real world, less regular adherence to treatment, more heavily pre-treated patients and resistance to treatment make these dual therapies prescribed beyond the strict framework of clinical trials. This can lead to undesirable side effects. From the perspective of personalized medicine, it seems to be important to determine which patients are receiving dual ARV therapy, and which patients remain on it for a long time. Identifying prognostic factors would enable us to adapt therapeutic management.

Enrollment: 580 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hiv patient
• viral load < 50copies/ml
• patient treated with dual therapy
• patients with hospital follow-up between 2011 and 2023

Exclusion criteria

• adults under legal protection
• underage