Dynamic Aspects of Amino Acid Metabolism

National Center for Research Resources (NCRR)

Status: Unknown

Conditions: Kidney Diseases

Study type: Observational

Funder types: NIH

Identifiers

NCT00005767

NCRR-M01RR00109-0740

M01RR000109 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• normal weight-for-height weight 50-80 kg
• normal physical activity
• no significant medical history
• healthy by medical exam and lab blood testing

Exclusion criteria

• subjects who exercise vigorously
• subjects who smoke