Dynamic Changes of Ductus Arteriosus in < 31 Weeks Preterm Infants: an Observational Study (PDA)

Army Medical University of People's Liberation Army

Status: Active, not recruiting

Conditions: Preterm; Ductus Arteriosus

Treatments: Other: observation group; Other: control group

Study type: Observational

Funder types: Other

Identifiers

NCT06950164

ductus arteriosus

Details and patient eligibility

About

The ductus arteriosus quickly closes itself. is an important channel connecting the maternal fetal circulation before birth. After birth, this ductus arteriosus generally no longer has a physical function, so ductus arteriosus quickly closes itself. The persistent presence of ductus arteriosus leads to significant pressure changes in the systemic and pulmonary circulation, which have adverse effects on extremely/very premature infants. Therefore, persistent patent ductus arteriosus (PDA) is a systemic disease.

Full description

hemodynamic significant PDA(hsPDA) is a risk factor for intraventricular hemorrhage(IVH), bronchopulmonary dysplasia(BPD), necrotizing enterocolitis(NEC). A meta-analysis from Cochrane shows that compared to conservative treatment, drug therapy for PDA within 3 and 7 days after birth does not promote PDA closure and reduce the incidence of BPD. Therefore, there is currently a tendency not to provide medication intervention. Although ductus arteriosus quickly closes itself after birth in normal term infants, however, the dynamic changes detail of ductus arteriosus in preterm infants are unknown.

Enrollment: 200 estimated patients

Sex: All

Ages: 1 minute to 1 hour old

Volunteers: No Healthy Volunteers

Inclusion criteria

• less than 32 weeks' gestational age
• admission with 1 hours after birth

Exclusion criteria

• congenital abnormalities
• parents' refusal

Trial design

200 participants in 2 patient groups

observation group

Description:

in the group, no intervention was given, and the preterm infants were diagnosed with respiratory distress syndrome(RDS)

Treatment:

Other: observation group

control group

Description:

in the group, no intervention was given, but the preterm infants were diagnosed without respiratory distress syndrome(RDS)

Treatment:

Other: control group