Dynamic Contrast Enhanced Computed Tomography to Assess Radiation Therapy in Liver Cancer Patients

University of Colorado Denver (CU Denver)

Status and phase: Completed; Early Phase 1

Conditions: Liver Cancer

Treatments: Diagnostic Test: Dynamic Contrast Enhanced Computed Tomography

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03891654

18-2874.cc

P30CA046934 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This is a pilot study that uses a standard of care technique, Stereotactic Body Radiation Therapy (SBRT), in combination with Dynamic Contrast Enhanced Computed Tomography (DCE-CT) to determine if perfusion changes from SBRT of liver cancer may be used for outcome assessment and prediction of prognosis.

Full description

Patients will undergo standard of care SBRT while also receiving DCE-CT, also known as perfusion CT, pre-treatment, 6 hours post-treatment and 6 weeks post-treatment.

Enrollment: 3 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Provision to sign and date the consent form
2. Stated willingness to comply with all study procedures and be available for the duration of the study
3. Be a Male or Female aged 18-100
4. Diagnosed with Liver HCC or metastases
5. Must be receiving or will plan to receive SBRT for Liver HCC or metastases

Exclusion criteria

1. Allergy to iodine contrast
2. CT with contrast not offered as a Standard of Care
3. Pregnant women

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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3 participants in 1 patient group

Dynamic Contrast Enhanced Computed Tomography

Experimental group

Description:

DCE-CT, also known as perfusion CT, is a functional imaging modality that uses repeated computed tomography imaging after injection of an iodine based contrast agent.

Treatment:

Diagnostic Test: Dynamic Contrast Enhanced Computed Tomography