Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

Assiut University

Status: Unknown

Conditions: Pulmonary Disease, Chronic Obstructive

Treatments: Device: Mechanical ventilator

Study type: Observational

Funder types: Other

Identifiers

NCT03230617

EDHMVCP

Details and patient eligibility

About

Chronic obstructive pulmonary disease is a common respiratory condition that is characterized by inflammation of the large and small peripheral airways , the alveoli and adjacent capillary networks. Severe airflow obstruction that imposes a significant load on the respiratory system is a major manifestation of Chronic obstructive pulmonary disease. The reduced expiratory airflow also causes air trapping at the end of expiration , producing alveolar pressure that are higher than atmospheric pressure before the next breath. This condition is intrinsic positive end-expiratory pressure .

Enrollment: 100 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient with acute exacerbation of Chronic obstructive pulmonary disease and respiratory failure who are intubated and mechanically ventilated.

Exclusion criteria

• patient with neuromuscular diseases.
• patient with pulmonary vascular diseases e.g pulmonary embolism.

Trial design

100 participants in 2 patient groups

Intrinsic positive end expiratory pressure > 5

Description:

chronic obstructive pulmonary disease patient with intrinsic positive end expiratory pressure more than5

Treatment:

Device: Mechanical ventilator

Auto positive end expiratory pressure < 5

Description:

chronic obstructive pulmonary disease patient with intrinsic positive end expiratory pressure less than5

Treatment:

Device: Mechanical ventilator