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Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

A

Assiut University

Status

Unknown

Conditions

Pulmonary Disease, Chronic Obstructive

Treatments

Device: Mechanical ventilator

Study type

Observational

Funder types

Other

Identifiers

NCT03230617
EDHMVCP

Details and patient eligibility

About

Chronic obstructive pulmonary disease is a common respiratory condition that is characterized by inflammation of the large and small peripheral airways , the alveoli and adjacent capillary networks. Severe airflow obstruction that imposes a significant load on the respiratory system is a major manifestation of Chronic obstructive pulmonary disease. The reduced expiratory airflow also causes air trapping at the end of expiration , producing alveolar pressure that are higher than atmospheric pressure before the next breath. This condition is intrinsic positive end-expiratory pressure .

Enrollment

100 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patient with acute exacerbation of Chronic obstructive pulmonary disease and respiratory failure who are intubated and mechanically ventilated.

Exclusion criteria

  • patient with neuromuscular diseases.
  • patient with pulmonary vascular diseases e.g pulmonary embolism.

Trial design

100 participants in 2 patient groups

Intrinsic positive end expiratory pressure > 5
Description:
chronic obstructive pulmonary disease patient with intrinsic positive end expiratory pressure more than5
Treatment:
Device: Mechanical ventilator
Auto positive end expiratory pressure < 5
Description:
chronic obstructive pulmonary disease patient with intrinsic positive end expiratory pressure less than5
Treatment:
Device: Mechanical ventilator

Trial contacts and locations

1

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Central trial contact

Aliae Abd Rabou, MD; Suzan Salama, MSc

Data sourced from clinicaltrials.gov

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