Dynamic MRI of the Behaviour of Female Pelvic Floor

Kuopio University Hospital

Status and phase: Completed; Early Phase 1

Conditions: Genital Prolapse; Stress Urinary Incontinence

Treatments: Procedure: movement of midurethra, bladder neck, cervix and rectum

Study type: Interventional

Funder types: Other

Identifiers

NCT00747370

KUH5302421

Details and patient eligibility

About

The purpose of this study was to test the suitability of dynamic magnetic resonance imaging for the pelvic floor floor, bladder neck and urethra in healthy volunteers, in stress incontinent patient and in women with genital prolapse.

Full description

Traditional methods for evaluation of urinary incontinence in women include urodynamics, cystourethroscopy, cystourethrography and ultrasonography.Magnetic resonance imaging (MRI) offers a new tool for evaluation of morphology and function of the urogenital compartment of the female pelvis. Moreover, MRI gives opportunity to study function of the pelvic floor organs in terms of mobility and reactions during different physiological and provocative activities.

The aim of the present study was by means of dynamic MRI to evaluate the behaviour of the mid-urethra, bladder neck, cervix and rectum in different maneuvers in three different study groups. Sixteen healthy volunteers with no complaints of urinary symptoms or urogenital prolapses, 42 stress urinary incontinence patients and 16 women with third degree genital prolapse were examined respectively.

Enrollment: 74 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy women without any urogenital symptoms
• stress urinary incontinence ( group II )
• genital prolapse of third degree ( group III)

Exclusion criteria

• previous incontinence or prolapse surgery
• lower urinary tract anomaly
• current UTI or > 3 UTI episodes within the past year
• previous radiation therapy of the pelvis
• active malignancy
• neurogenic disease which can be associated with bladder disorders
• patient unable to understand the purpose of the study
• patient immobile

Trial design

74 participants in 3 patient groups

1

Other group

Description:

16 healthy volunteers with no complaints of urinary symptoms and without urogenital prolapse of more than first degree.

Treatment:

Procedure: movement of midurethra, bladder neck, cervix and rectum

2

Other group

Description:

Forty two stress urinary incontinence patients without prior urogenital prolapse or incontinence operation and without genital prolapse more than first degree

Treatment:

Procedure: movement of midurethra, bladder neck, cervix and rectum

3

Other group

Description:

16 genital prolapse women without prior prolapse operations or any symptoms of incontinence

Treatment:

Procedure: movement of midurethra, bladder neck, cervix and rectum