Dynamic Preload Indicators in Sitting Position

Civil Hospices of Lyon

Status: Completed

Conditions: Neurosurgery in Sitting Position

Treatments: Procedure: Sitting position (neurosurgery)

Study type: Interventional

Funder types: Other

Identifiers

NCT02000570

2013.813

2013-A00937-38 (Other Identifier)

Details and patient eligibility

About

Intraoperative optimization of cardiac output using goal directed fluid challenge is associated with better outcome. Dynamic preload dependence indicators are well validated during surgery in supine position. Positioning from supine to sitting position under anesthesia is responsible of several hemodynamic changes. Predictability and cut-off values of dynamic preload dependence indicators during surgery in sitting position are unknown. The objective of this prospective study is to evaluate ability of three dynamic preload dependence indicators, i.e. PPV (Pulse Pressure Variation), SVV (Stroke Volume Variation) and PVI (Plethysmographic Variability Index), during neurosurgery in sitting position.

Full description

The primary objective is to determine PPV, SVV and PVI thresholds for which patients respond to fluid challenge in sitting position.

The secondary objectives are to determine variations of PPV, SVV and PVI measures before and after positioning in sitting position, and to compare these values to each other.

Enrollment: 31 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• neurosurgery in sitting position
• age > 18

Exclusion criteria

• arrhythmias
• severe heart failure
• severe lung disease
• contraindications to esophageal Doppler monitoring probe insertion (i.e. esophageal weakness)
• renal failure

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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31 participants in 1 patient group

sitting position

Experimental group

Treatment:

Procedure: Sitting position (neurosurgery)