Dyslipidemia and Diabetic Retinopathy (D&D)

The University of Alabama at Birmingham

Status

Completed

Conditions

Dyslipidemia

Diabetic Retinopathy

Treatments

Other: 15 subjects with Non Proliferative Diabetic Retinopathy(mild, moderate and severe). 15 subjects with Proliferative Diabetic Retinopathy

Other: Healthy Controls 15 age matched control subjects

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT03403283

300000188

5R01EY016077 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to determine if the reparative cells of blood vessels called endothelial progenitor cells(EPC) are defective in people with diabetes.

Full description

The purpose of this study is to determine if the reparative cells of blood vessels, called endothelial progenitor cells (EPC's) are defective in people with diabetes. Diabetic retinopathy (DR) is an eye disease related to diabetes. It can cause blurred vision and possible bleeding in the blood vessels in the back of the eye (retina). Damage to the cells of the blood vessels from DR can cause vision loss or blindness. Even with current treatments, the quality of life for people with DR is much reduced.

Enrollment

45 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Any man or woman
Greater than 18 years of age
Diagnosis of diabetes (applies to the Diabetic Arm only) (N=15 Type 1 and N=15 Type
The subject must be willing and have the ability to cooperate with the protocol. Children will not be eligible because the investigators need to obtain 150 ml of blood and this is in excess of what can be drawn in children.

Exclusion criteria

Female participants must not be pregnant at the time of the blood draw as evident through a dipstick pregnancy test.
Have retinal abnormalities other than diabetic retinopathy.