E-cadherin and Integrin Alpha v Beta 1 in Vitiligo

Kasr El Aini Hospital

Status: Unknown

Conditions: Vitiligo

Treatments: Device: Narrow band UVB

Study type: Interventional

Funder types: Other

Identifiers

NCT05287776

EcadVitiligo

Details and patient eligibility

About

The purpose of this clinical trial is to study the effect of Narrow Band UVB on E-cadherin and integrin alpha v beta 1 as representatives of adhesion molecules in non-segmental vitiligo in a trial to verify a novel proposed mechanism of Narrow Band UVB. Additionally, specific melanocyte marker (Melan A) will be done to settle the localization of adhesion molecules in relation to melanocytes.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All clinically diagnosed cases of non-segmental vitiligo .
• Patients with VIDA +1 or more (new/expanding lesions active in time period of 6-12 months ago) will be included in the trial. Activity of vitiligo will be evaluated through Vitiligo Disease Activity (VIDA) Score.

Exclusion criteria

• Patients who have stable disease at the time of study i.e. no progression of existing disease or appearance of new lesions in the last six months.
• Patients receiving treatment for vitiligo 3 months prior to the study.
• Patients with contraindications for phototherapy.
• Patients with current/history of any systemic and/or dermatological diseases affecting the immune system as autoimmune diseases and malignancy.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Sequential Assignment

Masking: None (Open label)

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15 participants in 1 patient group

15 patients with vitiligo subjected to NB-UVB

Experimental group

Description:

Patients will be subjected to NB-UVB sessions 3 times weekly. The UVB dosing scheme in the patients receiving only NB-UVB treatment entailed initial dosing at 0.5 J/cm2 with increasing increments by 0.3 J/cm 2 every other session until faint erythema occurs.

Treatment:

Device: Narrow band UVB