E-cigarettes and Blood Vessel Function

University of California, Los Angeles (UCLA)

Status: Completed

Conditions: Nicotine Dependence

Treatments: Other: one time exposure to empty e-cig; Other: one time exposure to e-cig with nicotine; Other: one time exposure to e-cig without nicotine

Study type: Interventional

Funder types: Other

Identifiers

NCT02740595

14-000743

Details and patient eligibility

About

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.

Full description

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.

Enrollment: 148 patients

Sex: All

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy

Exclusion criteria

• Cardiac disease
• Respiratory disease
• Diabetes mellitus

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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148 participants in 3 patient groups

Nicotine

Experimental group

Description:

Use an e-cig filled with liquid with nicotine

Treatment:

Other: one time exposure to e-cig with nicotine

no nicotine

Experimental group

Description:

Use an e-cig filled with liquid without nicotine

Treatment:

Other: one time exposure to e-cig without nicotine

sham comparator

Sham Comparator group

Description:

Use an empty e-cigarette (sham control)

Treatment:

Other: one time exposure to empty e-cig