E-Cigarettes and SNA

University of California, Los Angeles (UCLA)

Status: Completed

Conditions: Nicotine Dependence

Treatments: Other: one time exposure to empty e-cigarette; Other: one time exposure to e-cig with nicotine; Other: One time exposure to e-cigarette without nicotine

Study type: Interventional

Funder types: Other

Identifiers

NCT02724241

14-000731

Details and patient eligibility

About

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.

Full description

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.

Enrollment: 100 patients

Sex: All

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Healthy

Exclusion criteria

• Cardiac disease
• Respiratory disease
• Diabetes mellitus

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

100 participants in 3 patient groups

nicotine

Experimental group

Description:

use of an e-cigarette filled with liquid with nicotine

Treatment:

Other: one time exposure to e-cig with nicotine

no nicotine

Experimental group

Description:

Use of an e-cigarette filled with liquid without nicotine

Treatment:

Other: One time exposure to e-cigarette without nicotine

sham comparator

Sham Comparator group

Description:

Use of empty e-cigarette (sham control)

Treatment:

Other: one time exposure to empty e-cigarette