E-nose Utility in the Diagnosis of Bacterial Infection in COPD

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Status: Unknown

Conditions: Pulmonary Disease, Chronic Obstructive (COPD)

Treatments: Device: enose

Study type: Interventional

Funder types: Other

Identifiers

NCT01976117

IIBSP-ENO-2009-21

Details and patient eligibility

About

Hypothesis: A commercial e-nose (Cyranose 320) is able to detect specific breathprints from patients with COPD and bacterial infection

Full description

Thirty to 50% of COPD patients have airway colonization with potentially pathogenic bacteria. This is associated with worse prognosis. Currently, diagnosis of bacterial colonization relies mainly upon quantitative sputum culture. However, this method lacks good sensitivity. The electronic nose is a novel device made up of nanosensors capable of detecting specific volatile organic compounds (VOCs). OBJECTIVES: Main 1) To assess the usefulness of the electronic nose in the diagnosis of bacterial colonization in COPD. Secondary 1) To define the VOCs pattern associated with bacterial colonization. 2) To study the pattern of pulmonary and systemic inflammation associated with bacterial colonization as well its relationship with the aforementioned VOCs patterns.

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• COPD patients

Exclusion criteria

• Exacerbation in the last 4 weeks

Trial design

0 participants in 1 patient group

enose

Experimental group

Treatment:

Device: enose