Early- and Late-onset Candidemia

Giovanni Di Perri

Status: Completed

Conditions: Candidemia

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01406093

EOC1-11

Details and patient eligibility

About

A timing diagnosis of candidemia is as important as the correct choice of empiric or targeted antifungal therapy. In the last years a growing body of knowledge has better characterized health-care associated (HCA) infections, which have been described in 2002 in outpatients with MRSA bloodstream infections. So far there is no compelling evidence that patients with HCA infections may develop candidemia before the usual timing of around 20-25 days after admission. Risk factors associated with HCA infections are represented by admission from long term chronic care facilities (LTCF), haemodialysis, previous admission or parenteral broad spectrum antibiotics. There are few data HCA features and early onset candidemias in the published literature.

In this proposal, the investigators aim at studying early-onset candidemia in a retrospective study in one of the largest referral hospital in Italy with a consistent range of specialties ranging (bone marrow transplant, solid organ transplant, immunosuppressed patients, ICU, complex surgery). The investigators speculate that patients with candidemia diagnosed within 10 days (early-onset) by the admission have different risk factors and prognosis of those with a late diagnosis.

Enrollment: 400 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Candidemia diagnosed with positive blood culture either from a peripheral vein or CVC

Exclusion criteria

• Candida isolated from a removed CVC tip will not be considered

Trial design

400 participants in 1 patient group

Candidemia patients

Description:

Patients with diagnosis of candidemia