Early COPD for China Pulmonary Health Study Stage II (EC-CPHS)

China-Japan Friendship Hospital

Status: Enrolling

Conditions: Obstructive Pulmonary Disease

Study type: Observational

Funder types: Other

Identifiers

NCT05028985

82090011

Details and patient eligibility

About

Discovery of the pathogenesis and targets in the progression of early chronic obstructive pulmonary disease

Full description

This project is aimed to investigate and explore the heterogeneity during the progression of Chronic Obstructive Pulmonary Disease (COPD) in the early stage, utilizing the large-scale population cohort databases (including "China Pulmonary Health study", "The Cohort Study for Chronic Obstructive Pulmonary Disease in China" and "Acute Exacerbation of COPD Patient Registry in China" ), biological sample libraries(including blood, sputum, expiratory air, bronchoalveolar lavage fluid(BALF), and lung tissue from COPD patients with different stages and phenotypes), and multi-omics sequencing (including scRNA-seq, metabolomics, proteomics, and metagenome). We propose to establish a new standard for COPD stages and subtypes. By analyzing and mining the multi-omics data, it is expected to illustrate the association between clinical phenotype and molecular, cellular and tissue heterogeneities, thus reveal biomarkers related to the progression, clinical phenotypes, and prognosis of early-stage COPD disease.In addition, we will construct different types and stages of COPD animal models for further mechanism studies, such as the different pathogenic factors, innate and adaptive immunity, and the airway microbial ecosystem, so that we can discovered more potential therapeutic target for early-stage COPD. This project can bring a new insight and scientific evidence for COPD treatment.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• younger than 50 years
• smoking more than 10 pack-years
• early airflow limitation(post-bronchodilator FEV1/FVC< lower limit of normal)

Exclusion criteria

• cancer
• other respiratory diseases
• mental illness

Trial design

400 participants in 2 patient groups

early COPD patients

Description:

younger than 50 years with 10 or more pack-years smoking history and any of these abnormalities: 1) early airflow limitation (post-bronchodilator forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC) \< lower limit of normal), 2) compatible CT abnormalities, 3) rapid decline in FEV1 (≥60 ml/yr).

Healthy people

Description:

healthy without any disabling, physical, neurological, or mental disease and were excluded living in a nursing home.