Early Coronary Angiography in Advanced Chronic Kidney Disease With Acute Coronary Syndrome (CAG in CKD-ACS)

Chulalongkorn University

Status: Completed

Conditions: ACS (Acute Coronary Syndrome); CKD; Coronary Angiography (CAG)

Treatments: Procedure: coronary angiography

Study type: Observational

Funder types: Other

Identifiers

NCT07474441

046367

0463/67 (Other Identifier)

Details and patient eligibility

About

This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute coronary syndrome.

Full description

Electronic medical records of adult patients admitted with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital, Thailand, were retrospectively reviewed. Eligible patients should have concurrent advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m² calculated by the 2021 CKD-EPI creatinine equation.

Enrollment: 139 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m²
• Diagnosis with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital

Exclusion criteria

• Received maintenance dialysis or kidney transplantation before admission
• Cardiogenic shock or cardiac arrest
• Prior PCI or CABG within 12 months
• Recently diagnosed with ACS within 2 months
• Had a limited life expectancy due to non-cardiovascular disease
• Pregnant.

Trial design

139 participants in 3 patient groups

Early coronary angiography

Description:

Recieve coronary angiography within 24 hours of admission

Treatment:

Procedure: coronary angiography

Delayed coronary angiography

Description:

Recieve coronary angiography later than 24 hours of admission

Treatment:

Procedure: coronary angiography

Conservative management

Description:

Medical management without coronary angiography