Early Detection and Intervention for Women At-risk of Psychosis

The University of Hong Kong (HKU)

Status: Unknown

Conditions: Prodromal Schizophrenia

Treatments: Behavioral: Psychoeducation; Behavioral: CBT

Study type: Interventional

Funder types: Other

Identifiers

NCT03751865

JCWowCBT

UW 18-231 (Other Identifier)

Details and patient eligibility

About

This study aims to examine the effectiveness of the cognitive behavioral therapy in preventing the conversion of psychosis in a sample of individuals at-risk for psychosis.

Full description

Eligible subjects with informed consent provided will be randomly assigned to the cognitive behavioural therapy (CBT) group or psychoeducation group. Each group consists of 8 session spanning for 8 week.

Enrollment: 160 estimated patients

Sex: Female

Ages: 18 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women of age 18-64
• at-risk mental state as defined by the Comprehensive Assessment of At-Risk Mental States (CAARMS)
• with an informed consent
• able to understand Cantonese and read/write Chinese

Exclusion criteria

• those mental conditions that requires other treatment priorities (e.g., suicidal risk, substance abuse, current or past episodes of psychotic disorder, personality disorders)
• those medical conditions that severely limits participation, comprehension, or adherence to the treatment (e.g., epilepsy, dementia, terminal medical illness);
• those who are receiving structured psychotherapy or counselling

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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160 participants in 2 patient groups

CBT group

Experimental group

Description:

This intervention aims for distress reduction, symptom coping, and life quality enhancement. It is a gender-specific CBT tailor-made for the at-risk population. The intervention is delivered by a registered clinical psychologist.

Treatment:

Behavioral: CBT

Psychoeducation group

Active Comparator group

Description:

The content of the psycho-education program will be related to healthy living content and mental health knowledge, such as food hygiene, psychological well-being, knowledge about psychosis and common mental disorder and food nutrition. In addition, a weekly call to remind the subject about healthy living will also be provided to the subjects. The intervention is delivered by a registered social worker.

Treatment:

Behavioral: Psychoeducation