Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder

New York State Psychiatric Institute

Status

Completed

Conditions

Bipolar Disorder

Depression

Treatments

Behavioral: Educational clinical monitoring

Behavioral: Interpersonal psychotherapy for prevention with adolescents

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00338806

K23MH071530 (U.S. NIH Grant/Contract)

#5067

Details and patient eligibility

About

This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder.

Full description

Bipolar Disorder (BD) is a serious medical illness that causes drastic shifts in a person's mood, energy, and ability to function. BD symptoms alternate from increased energy, restlessness, and overly good mood to a lasting sad, anxious, or empty mood and feelings of hopelessness or pessimism. Research suggests that children of parents with BD are at risk for developing mood disorders because of predisposing genetic factors and stressful life events, many of which may be related to their parents' unstable clinical state. Adolescent children of parents with BD must deal simultaneously with the difficult task of negotiating their own developmental transitions, as well as living with a parent with BD. It may be possible to detect symptoms of BD or other mood disorders early in adolescence and prevent the disorder from further interfering with someone's life. This study will develop and refine strategies for early detection and primary prevention of mood disorders and associated impairment in adolescent children of parents with BD.

Participants in this single-blind study will be randomly assigned to receive either interpersonal psychotherapy with adolescents (IPT-PA) or a control intervention, educational clinical monitoring (ECM), for 12 weeks. Participants assigned to IPT-PA will attend twelve sessions. The first four sessions will last 90 minutes each, and will include both family psychoeducation and individual psychotherapy with the adolescent. The remaining sessions will be 45 minutes each, and will include only individual psychotherapy with the adolescent. Participants assigned to ECM will each be assigned to a therapist. During the initial two sessions, which will take place over 2 consecutive weeks, the therapist will focus on mood disorder psychoeducation and participants will receive related written educational material. Participants will then meet with their therapists monthly for 30-minute sessions. Symptoms and functioning will be assessed, but no assistance on building interpersonal skills will be provided. A participant may request a second session each month, but if more than two monthly sessions are required, the participant will be referred for therapy. Mood episodes and symptoms, symptom severity, and functioning will be assessed for all participants at Weeks 6 and 12 and Months 6, 12, and 18 post-treatment.

Enrollment

7 patients

Sex

All

Ages

12 to 17 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for Parents:

Diagnosis of BD I or II
Currently in partial or full remission from a depressive or manic episode
Under active clinical care

Inclusion Criteria for Adolescents:

Speaks English or Spanish
Presence of at least one current mood symptom meeting DSM-IV Criterion A and at least one depression or mania symptom meeting DSM-IV Criterion B
Depression, irritability, anhedonia, or elated mood scored at level 2 or 3 on the KSADS-PL
Mania symptom scored at level 2 or 3 on the KSADS-PL scale
Score of less than 40 on the CDRS-R scale
Score of less than 15 on the YMRS scale
Mild-moderate functional impairment, defined as a score of greater than 61 and less than 75 on the C-GAS scale

Exclusion Criteria for Parents:

History of psychosis within 1 month of study entry
At risk for suicide within 1 month of study entry

Exclusion Criteria for Adolescents:

Past major depressive or manic episode
Current or past psychosis
History of suicide attempts
Current substance use disorder
Use of psychotropic medications and other medications that might impact mood (e.g., steroids)