Early Detection and Risk Stratification of Colorectal Cancer Based on miRNA Platform

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Zhejiang University

Status

Not yet enrolling

Conditions

Colorectal Cancer

Treatments

Device: miRNA detection test

Study type

Observational

Funder types

Other

Identifiers

NCT06351384
20230744

Details and patient eligibility

About

This is a prospective, observational cohort study to establish the minimal residual disease (MRD) model for predicting relapse risk and identifying disease recurrence in patients with colorectal adenocarcinoma based on the miRNA platform. Blood miRNA markers will be evaluated. The study will enroll approximately 600 participants, including participants with malignancies or benign diseases, and healthy participants.

Enrollment

600 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Inclusion Criteria for the colorectal cancer arm:

1.18-75 years old 2. Pathologically confirmed as colorectal adenocarcinoma 3. Medically able to receive radical surgery for colorectal cancer 4. Eastern Cooperative Oncology Group (ECOG) performance-status score of 0 to 1 5. Ability to provide a written informed consent

Inclusion Criteria for the healthy control arm:

1.18-75 years old 2. No clinically significant finding based on routine blood tests, urinalysis, CT, and ultrasound examinations 3. Ability to provide a written informed consent

Inclusion Criteria for the intestinal polyp arm:

1.18-75 years old 2. Pathologically confirmed as colorectal adenoma 3. Ability to provide a written informed consent

Exclusion criteria

  1. History of other malignant tumors (excluding non-melanoma skin cancer).
  2. Prior or related treatments previously (including colorectal cancer or advanced adenoma surgery, endoscopic treatment, chemotherapy, targeted therapy, immunotherapy, radiation, neoadjuvant therapy, etc.).
  3. Patients with hereditary colorectal diseases (including Lynch syndrome, familial CRC type X (FCCX), familial adenomatous polyposis (FAP), MUTHY-associated polyposis (MAP), Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome (JPS), serrated polyposis syndrome (SPS), etc.).
  4. Usage of anti-tumor drugs such as methotrexate, cyclophosphamide, mercaptopurine, and bendamustine for other diseases within 30 days before blood collection.
  5. Prior blood transfusion (including blood components) within the past 2 weeks.
  6. Prior organ transplantation, bone marrow transplantation, or stem cell transplantation.
  7. Pregnancy women.
  8. Acute inflammation or fever requiring drug escalation within 14 days prior to blood collection.
  9. Inability to comply with study procedures such as blood collection and related examinations.
  10. Deemed unsuitable for participation in the clinical trial by the investigator.

Trial design

600 participants in 3 patient groups

Colorectal cancer arm
Treatment:
Device: miRNA detection test
Healthy control arm
Treatment:
Device: miRNA detection test
Intestinal polyp arm
Treatment:
Device: miRNA detection test

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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