Early Detection of Cardiac Damage With CMR in Women With Breast Cancer (EARLY-CATCH)

Radboud University Medical Center

Status: Unknown

Conditions: Cardiotoxicity; Breast Cancer; Chemotherapy Induced Systolic Dysfunction

Treatments: Diagnostic Test: CMR

Study type: Observational

Funder types: Other

Identifiers

NCT04046315

108818

Details and patient eligibility

About

With this study the investigators will assess early cardiac damage by means of Global Longitudinal Strain (GLS) in newly diagnosed breast cancer (BC) patients treated with anthracycline-based chemotherapy, and to investigate whether myocardial damage as measured with T1 / T2 Cardiovascular Magnetic Resonance (CMR) mapping and plasma hs-Troponin T is related to changes in GLS.

Enrollment: 55 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female
• Age ≥ 18 years
• A diagnosis of primary breast cancer
• Starting (neo-) adjuvant chemotherapy treatment within 2 months after screening
• Cardiotoxicity risk score of intermediate, high or very high risk

Exclusion criteria

• Previous radiotherapy or systemic cancer treatment
• Cancer metastasis
• Life expectancy of less than 6 months
• History of myocardial infarction or heart failure
• Known contra-indications for CMR
• Refusal or inability to provide informed consent