Early Detection of Glioblastoma Multiforme (GBM) Treatment Responses Using Multiple Magnetic Resonance Modalities

Yale University

Status: Terminated

Conditions: Glioblastoma Multiforme

Treatments: Other: dynamic contrast enhanced magnetic resonance imaging

Study type: Observational

Funder types: Other

Identifiers

NCT00589095

0606001531

Details and patient eligibility

About

The purpose of this study is to determine whether dynamic contrast enhanced MRI (DCE MRI) and high diffusion weighting MRI may be used to distinguish between favorable and unfavorable responses to therapy of glioblastoma multiforme. Imaging data will be correlated with histopathologic findings and clinical responses to radiation therapy with or without chemotherapy.

Enrollment: 5 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The presence of a primary brain tumor that cannot be completely resected that requires radiation therapy with or without chemotherapy.

Exclusion criteria

• Patients who do not have a primary brain tumor or who are unable to tolerate the environment of the MRI scanner

Trial design

5 participants in 1 patient group

1

Treatment:

Other: dynamic contrast enhanced magnetic resonance imaging