Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Imaging

Mayo Clinic

Status: Completed

Conditions: Pulmonary Hypertension; Pulmonary Arterial Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT01451255

11-002576

Details and patient eligibility

About

Cardiac magnetic resonance imaging has emerged as a potential valuable test for the early detection of Pulmonary Arterial Hypertension. A number of reports have provided some preliminary evidence that Pulmonary Artery (PA) stiffness may be accurately detected by imaging of the pulmonary artery in order to measure PA stiffness. In addition, cardiac MRI could play provide early and effective treatment for Pulmonary Arterial Hypertension (PAH).

Enrollment: 90 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Consecutive patients aged ≥ 18 years with PAH as dictated by a comprehensive examination and echocardiography will be included for enrollment.

Exclusion criteria

• Age < 18 years
• Pregnancy
• Mechanical ventilation
• Acute or chronic renal failure (creatinine clearance < 30 ml/min or requiring renal replacement therapy)
• Inability to perform MRI (i.e. claustrophobia, severe obesity (> 150 kg), device incompatible with MRI)
• Significant arrhythmia that precludes adequate ECG-gating for the MRI (i.e. atrial fibrillation with highly variable cycle lengths)
• Prior heart or lung transplantation
• Left ventricular systolic (ejection fraction < 50%) or diastolic failure (based on Framingham criteria for heart failure with preserved ejection fraction)
• Significant left-sided valvular disease (≥ moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation) or prior valve surgery