Early Diabetes Resolution After Weight Loss Surgery

Vanderbilt University Medical Center

Status: Completed

Conditions: Diabetes; Obesity

Treatments: Procedure: Laparoscopic abdominal surgeries; Procedure: Weight loss surgery

Study type: Observational

Funder types: Other

Identifiers

NCT00790309

NNA-Early DM Resolution

Details and patient eligibility

About

The primary objective is to compare inflammatory, hormonal, and metabolic changes in the very short term after various bariatric surgical procedures (Roux-en Y Gastric Bypass, Vertical Sleeve Gastrectomy, and Adjustable Gastric Banding)and other abdominal surgeries, as well as to compare these changes to diet-induced changes in the same population.

Enrollment: 75 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for surgery groups:

• BMI of 30 kg/m2 or higher
• Ages 18-65
• History of impaired glucose tolerance or T2DM

Inclusion Criteria for normal weight group:

• BMI of 30 kg/m2 or lower
• Ages 18-65

Exclusion Criteria:

• Development of an intercurrent infection
• Prior gastric, duodenal, proximal jejunal surgery or pancreas resection
• Current use of thiazolidinediones
• Current use of dipeptidyl peptidase-IV inhibitors (e.g., sitagliptin) or glucagon-like peptide-1 analogs (e.g., exenatide)
• Any condition felt by the PI or co-investigators to interfere with ability to complete the study

Trial design

75 participants in 3 patient groups

Weight loss surgery

Description:

This group will be comprised of people having weight loss surgery: Roux-en Y gastric bypass, vertical sleeve gastrectomy, or adjustable gastric banding

Treatment:

Procedure: Weight loss surgery

Abdominal surgery

Description:

This group will be comprised of people having abdominal surgeries such as nissen fundoplication or cholecystectomy.

Treatment:

Procedure: Laparoscopic abdominal surgeries

Lean

Description:

This group will be comprised of normal weight healthy volunteers.