Early Diagnosis of Asthma in Young Children

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Asthma

Treatments: Drug: beclomethasondipropionate

Study type: Interventional

Funder types: Other

Identifiers

NCT00422747

NL17407.000.07/2007-001817-40

Details and patient eligibility

About

The overall aim of the study is an early asthma diagnosis in young children by the use of non-invasive biomarkers of airway inflammation /oxidative stress in exhaled air, and early lung function measurements

Enrollment: 202 patients

Sex: All

Ages: 2 to 4 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children aged 2-3 years, with recurrent respiratory symptoms suggestive of asthma
• Children aged 2-3 years, with no or minor respiratory symptoms

Exclusion criteria

• Mental retardation
• Cardiac anomalies
• Congenital malformations
• Other diseases of the lungs/airways
• Chronic systemic inflammatory diseases like M. Crohn
• The inability to perform lung function measurements and/or exhaled air collection

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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202 participants in 1 patient group

beclomethasondipropionate

Experimental group

Description:

2 x 100 ug dd for two months, via aerochamber

Treatment:

Drug: beclomethasondipropionate