Early Diagnosis of Gastric Cancer Cachexia

Air Force Military Medical University of People's Liberation Army

Status: Enrolling

Conditions: Cachexia

Treatments: Other: cachexia

Study type: Observational

Funder types: Other

Identifiers

NCT06277986

KY20212018-F-2

Details and patient eligibility

About

Gastric cancer is one of the most common malignancies, the morbidity and mortality of which are among the highest. In cancer patients, the incidence of cachexia is very high, and even 80% of patients will eventually develop into cachexia. However, once gastric cancer patients develop cachexia, patients are unlikely to obtain clinically significant benefits from conventional treatment. Therefore, it is important to find biomarkers for early detection of cachexia. The investigators carried out a plasma-derived exosomal microRNA(miRNA) study for early diagnosis of cachexia in gastric cancer, and the development of early diagnosis kits for gastric cancer cachexia.

Full description

Gastric cancer is one of the most common malignancies, the morbidity and mortality of which are among the highest. In gastric cancer patients, the incidence of cachexia is very high, and even 80% of patients will eventually develop into cachexia. However, once gastric cancer patients develop cachexia, patients are unlikely to obtain clinically significant benefits from conventional treatment. Therefore, it is important to find biomarkers for early detection of cachexia. The investigators carried out a plasma-derived exosomal microRNA(miRNA) study for early diagnosis of cachexia in gastric cancer, and the development of early diagnosis kits for gastric cancer cachexia.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with gastric cancer diagnosed by histopathology or cytopathology
2. Complete clinical and pathological data
3. No previous or current mental illness or disturbance of consciousness

Exclusion criteria

1. With multiple tumors or other malignant diseases
2. Combined with other chronic wasting and metabolic diseases
3. Past patients with non-tumor cachexia
4. People with mental illness or unable to cooperate

Trial design

150 participants in 2 patient groups

Gastric cancer patients with non-cachexia

Treatment:

Other: cachexia

Gastric cancer patients with cachexia

Treatment:

Other: cachexia