Early Diagnosis of Patients With Mild Cognitive Impairment Through the Parameterization of Functional Tests.

University of Malaga

Status: Withdrawn

Conditions: Mild Cognitive Impairment

Treatments: Procedure: Standard Care or Usual Clinical Practice

Study type: Interventional

Funder types: Other

Identifiers

NCT03851198

IJFA07

Details and patient eligibility

About

The present study aims to develop an index formed by the variables, functional tests, scales and instruments that best discriminate between healthy subjects and subjects with MCI and that allows the stratification of different levels of severity of MCI, and to validate new systems for the early diagnosis of subjects with mild cognitive impairment.

Full description

Dementia affects 46.8 million people and in 2050 it is expected that there will be between 115-135 million people suffering from dementia. Inside dementias, Mild Cognitive Impairment (MCI) has a prevalence in adults aged ≥65 years of 10-20%.

Patients with MCI also show greater progression towards dementia, higher mortality and disability, and a greater use of medical care compared to cognitively normal subjects that converts MCI into an important public health problem, which reinforces the need to perfect clinic assessment procedures to improve the early identification of individuals with MCI. Early diagnosis could allow effective medical treatments that prevent or slow the onset of dementia, and could improve the effectiveness of non-pharmacological interventions.

Currently, it can be used an Inertial Sensor and 3D motion capture systems with a camera to analyse kinematics and these instruments are being integrated as a rehabilitation tool in patients. The use of Inertial Sensor and 3D motion capture cameras would help to find fast and cheap assessment methods for professionals.

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects over 60 years of age.
• Healthy subjects and subjects diagnosed with mild cognitive impairment.
• Subjects able of filling out questionnaires and performing functional tests.

Exclusion criteria

• Participants with neurological pathologies other than mild cognitive impairment.
• Participation in an experimental study where they receive a treatment.
• Score on the Mini-Mental State Examination of less than 24.
• Inability to get up from the chair at least 5 times or 30 seconds
• Inability to walk 20 meters.
• Inability to raise up both arms to 90 degrees or lifting 2 kg with the hand.
• Inability to walk independently without a walking assistance device (cane, crutch or walker).
• Patients with prescription of beta-blockers.
• Inability to provide informed consent.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups

Mild Cognitive Impairment patients

Experimental group

Description:

Subjects diagnosed with mild cognitive impairment, who will receive the best treatment of clinical practice, will be recruited. They must be more than 60 years old.

Treatment:

Procedure: Standard Care or Usual Clinical Practice

Healthy Subjects/ Match control

Active Comparator group

Description:

Healthy subjects of the same age as people with mild cognitive impairment.

Treatment:

Procedure: Standard Care or Usual Clinical Practice