Early Endoscopic Indicators for OACs After Lung Transplantation: Development of a Novel Mucosal Healing Score

Thomas Fuehner

Status: Completed

Conditions: Airway Complication Which Require Any Intervention

Study type: Observational

Funder types: Other

Identifiers

NCT00940147

OAC_1.0

2008_01

Details and patient eligibility

About

Airway complications are a significant cause of morbidity after lung transplantation (LTx). Bronchoscopic evaluation may help to identify risk factors for requiring interventions later.

Full description

The investigators evaluated lung transplant recipients prospectively. Adult patients surviving 90 day after LTx will be included. The investigators propose a classification of airway healing based on the endoscopic bronchial appearances at days 7, 14, 21, 90, 180 and 365 after LTx. A score system including mucosal healing, full tissue necrosis (=dehiscence), lose sutures, fibrin plugs, polyps and malacia will be developed (max. score 8 points/date). Endoscopic findings will be correlated with the development of obstructive airway complications (OAC, requiring >1 intervention). Afterwards the new score system will be applied prospectively in the patients.

Enrollment: 180 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 3 month survivor after LTx
• no OAC

Exclusion criteria

Trial design

180 participants in 2 patient groups

1

Description:

patients with OAC, Score finding

2

Description:

patients without OAC, Score finding