Early Enteral Nutrition in Severe Acute Pancreatitis

Shanghai Jiao Tong University

Status: Unknown

Conditions: Pancreatitis

Treatments: Other: modified early enteral nutrition; Other: early enteral nutrition

Study type: Interventional

Funder types: Other

Identifiers

NCT02000323

RJpancreatitis02 (Other Identifier)

Details and patient eligibility

About

to compare different time points for enteral nutrition in SAP patients

Full description

There is increasing evidence that indicates Early Enteral Nutrition（EEN） may be associated with improved outcome in acute pancreatitis patients. However, some SAP patients failed to EEN. The researchers of this study aim to investigate the opportunity of EEN on the clinical outcomes of SAP patients.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Diagnosis of pancreatitis: Typical pain increase in serum lipase or amylase

2. Onset of abdominal pain within <=72h before admission

3. moderate severe or severe Acute Pancreatitis according to Atlanta criteria revisited in 2012 ffff

   Exclusion Criteria:

   • 1. Pregnancy 2.tumor 3. acute onset of chronic pancreatitis

4. chronic disease of any organ （heart lung gastrointestinal renal etc.） 5. Pre-existing disease with life expectancy < 3 months 7.receive parenteral nutrition or enteral nutrition before admitting

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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60 participants in 2 patient groups

early enteral nutrition

Active Comparator group

Description:

Naso-gastro-jejunal tube will be set up by X-ray within 24 hours of admission. * The distal end of the feeding tube would be placed at the remote end of Treitz ligament, and verified by X-ray. * After catharsis, Standard enteral nutrition liquid regimen （Peptisorb Liquid）will be used step by step. * Patients are targeted to receive calories for 25 kcal/kg/day.

Treatment:

Other: early enteral nutrition

modified early enteral nutrition

Active Comparator group

Description:

Naso-gastro-jejunal tube will be set up by X-ray within 24 hours of admission. * The distal end of the feeding tube would be placed at the remote end of Treitz ligament, and verified by X-ray. * After catharsis, Only Normal Saline were given through Naso-gastro-Jejunal tube until 2 or more followed requirements were met mean arterial pressure≥65mmHg; oxygenation index≥ 300;APCHEII≤8; intra-abdominal pressure \<20mmHg).Then Standard enteral nutrition liquid regimen (Peptisorb Liquid) will be used step by step. * Patients are targeted to receive calories for 25 kcal/kg/day.

Treatment:

Other: modified early enteral nutrition