Early Evaluation of the Response of Large B Cell Non Hodgkin's Lymphoma to Chemotherapy by PET/CT

Eric Turcotte

Status

Completed

Conditions

Lymphoma, Large-Cell

Treatments

Procedure: PET/CT 20 days after the first cycle of chemotherapy

Study type

Interventional

Funder types

Other

Identifiers

NCT00256490

CRC 05-020

CIMF 2005-01

Details and patient eligibility

About

Patients affected with non-Hodgkin's large B-cell lymphoma are treated by chemotherapy. The evaluation of the response to this treatment is made by Positron Emission Tomography (PET/CT) in many centres where this technology is available. Presently PET scans and CT scans are being performed before treatment, after 4 cycles of chemotherapy and a few months after the end of treatment.

The goal of this study is to determine if it is possible to evaluate the efficiency of chemotherapy treatments after one cycle of treatment instead of waiting after 4 cycles, using a new scanner that combines PET and CT modalities. Data available from studies on these combined exams suggest that PET/CT helps to rapidly evaluate the response of the chemotherapy treatment. We also want to verify if some pathological characteristics measured from tumor cells will enable doctors to predict in advance the response to treatment.

Full description

Participation in this study involves 4 PET/CT exams, which occur before the treatments start, after the first cycle of chemotherapy, after 4 cycles of chemotherapy and then 12 weeks after the end of the treatments. The only additional test performed in this study compared to the regular follow-up of patients that are not in this study is the PET/CT exam after the first cycle. Your participation in this study will not affect treatment since the results of the first PET/CT test will not be communicated. All other tests results will be available in the medical record.

Enrollment

82 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Newly diagnosed large B cells non Hodgkin's lymphoma, CD20 positive
Chemotherapy treatments planned (R-CHOP) but not started

Exclusion criteria

Pregnancy (determined by urinary β-HCG and blood test)
Patients younger than 18 years
Unable to tolerate the procedure (30 minutes laying down on the back)
No chemotherapy treatment planned secondary to the patient's health performance
Previous lymphoma that has been treated with chemotherapy with the exception of stade I lymphoma treated only with radiotherapy.
All lymphoma other than large cell Non Hodgkin's lymphoma