Early High-volume Continuous Veno-venous Hemofiltration for Patients With Severe Acute Pancreatitis (EHVCVVHSAP)

A

Air Force Military Medical University of People's Liberation Army

Status

Unknown

Conditions

Acute Pancreatitis

Treatments

Device: AN69 hemofilter
Other: conventional treatments

Study type

Interventional

Funder types

Other

Identifiers

NCT01595672
81170432 (Other Grant/Funding Number)
SAP-CVVH-XHDD-002

Details and patient eligibility

About

The purpose of this study is to determine the effect and safety of early high-volume continuous veno-venous hemofiltration for patients with severe acute pancreatitis.

Full description

The investigators anticipated that early high-volume continuous veno-venous hemofiltration (EHVCVVH) would result in a decrease of the composite of persistent organ failure or death by eliminating inflammatory mediators in blood. This study is designed to evaluate the impact of EHVCVVH on patients with severe acute pancreatitis.

Enrollment

56 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • clinical diagnosis of severe acute pancreatitis
  • written informed consent
  • Time from onset of abdominal pain to admission ≤ 72 hours
  • SIRS score ≥ 2

Exclusion criteria

  • confirmed infection
  • pregnancy
  • patients needing emergency operation for abdominal compartment syndrome
  • chronic renal diseases needing blood purification
  • previous exploratory laparotomy for acute abdomen and diagnosis of pancreatitis during laparotomy
  • acute flare-up of chronic pancreatitis
  • malignancy

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

56 participants in 2 patient groups

EHVCVVH group
Active Comparator group
Description:
Patients receive conventional treatments recommended by guidelines with adjunctive early high-volume continuous veno-venous hemofiltration (EHVCVVH).
Treatment:
Device: AN69 hemofilter
Control group
Active Comparator group
Description:
Patients receive conventional treatments recommended by guidelines only.
Treatment:
Other: conventional treatments

Trial contacts and locations

0

Loading...

Central trial contact

Zhao Qingchuan, PhD & MD; Zhang Xujie, MD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location

Resources

© Copyright 2024 Veeva Systems