Early Increase in Blood Supply in Patients With Barrett's Esophagus (EIBS in BE)

Mayo Clinic

Status: Completed

Conditions: Barrett's Esophagus

Study type: Observational

Funder types: Other

Identifiers

NCT01188980

09-005328

Details and patient eligibility

About

The purpose of this study is to determine if early Barrett's specialized intestinal metaplasia can be detected by measuring early increased blood supply of the esophageal tissue, with 4 Dimensional Elastic Light-Scattering Fingerprinting, (4D-ELF) technology in real time.

Enrollment: 90 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18 years or older,
• informed written consent,
• patient scheduled for previously planned upper endoscopy

Exclusion criteria

• liver disease;
• gastric antral vascular ectasia (GAVE);any known non-esophageal aerodigestive malignancy;
• severe cardiopulmonary disease precluding endoscopy; presence of conditions not allowing biopsy (e.g. coagulation disorder);
• known familial polyposis syndrome (FAP, HNPCC, Juvenile polyposis, etc.);
• known pregnancy or sexually active females of childbearing age who are not practicing an accepted form of birth control.

Trial design

90 participants in 3 patient groups

NoBE (control)

BE without dysplasia

BE with dysplasia