Early Intervention for Gestational Diabetes

Intermountain Health Care, Inc.

Status

Withdrawn

Conditions

Gestational Diabetes Mellitus

Treatments

Drug: Placebo

Drug: Metformin

Study type

Interventional

Funder types

Other

Identifiers

NCT01171456

1017118

Details and patient eligibility

About

Gestational diabetes (GDM) represents a significant and growing source nationwide of morbidity and mortality for both mothers and infants. Between 5 and 10% of pregnancies are complicated by GDM. Infants exposed in utero to hyperglycemia from GDM have an increased risk of neonatal complications as well as an increased prevalence of a number of chronic diseases, including type 2 diabetes and schizophrenia. Recent research shows that treatment with metformin begun as soon as hyperglycemia is detected in pregnancy is safe and effective. Additional studies demonstrated that metformin is able to decrease the incidence of type 2 diabetes among individuals at risk for this disease. Based upon these findings, the investigators propose to test the hypothesis that metformin therapy for women at risk for gestational diabetes, started prior to conception and before the onset of hyperglycemia, both decreases the incidence of and improves the maternal and neonatal outcomes from GDM.

The investigators intend to conduct a prospective, randomized, double-blind placebo controlled range-finding study to measure the effects of early metabolic intervention with metformin in women at risk for GDM before the commencement of pregnancy or prior to completion of the first trimester. The target sample size for this pilot study is 100 women. The effect size observed will provide preliminary data for a subsequent study which will be sufficiently powered to detect small or moderate effects from early metabolic intervention in women at risk for GDM.

The specific aims of the proposed research consist of the following:

Determine whether treating women at risk for GDM with metformin prior to conception and/or completion of the 1st trimester decreases the incidence of GDM at 26 weeks' gestation.
Evaluate the effects on maternal and fetal pregnancy outcomes of pre-conception metabolic intervention with metformin in women at risk for GDM.
Use these pilot study results to:
1. identify specific demographic characteristics associated with an intervention effect
2. calculate effect size for specific outcomes
3. provide range-finding data for a subsequent study design

Metformin therapy for women at risk for gestational diabetes, started prior to conception and before the onset of hyperglycemia, both decreases the incidence of and improves the maternal and neonatal outcomes from GDM.

Sex

Female

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Women delivered >37 weeks gestation in the Intermountain Healthcare Urban Central Region within the last 18 months to ascertain those at risk for GDM in their next pregnancy because of:

A history of gestational diabetes in their immediately prior pregnancy
A family history (i.e. type 2 diabetes in a first or second degree relative) of type 2 diabetes
Delivery of an infant > 4000 gms.
B.M.I. > 30 six months postpartum
Hemoglobin A1C > 6.1% six months postpartum

Exclusion criteria

Pre-conception exclusion criteria will include any of the following:

History of >1 miscarriage or fetal demise
No contraindication to metformin (prior metformin intolerance, metabolic acidosis, GI disease)
Hypertension (BP >135/85)
No other endocrine, metabolic, renal, or autommune medical disorders
Prior preterm birth
Prior delivery complicated by shoulder dystocia
Prior delivery complicated by neonatal palsy
Multifetal pregnancy, including first-trimester embryonic demise of one or more
Uterine malformations
Illicit drug or alcohol abuse during current pregnancy
Intent to deliver elsewhere
Non-availability for prospective specimen/data collection